Case Study

ReCODE + QuesGen

Reversal of Cognitive Decline (ReCODE): a prospective observational study using a comprehensive lifestyle-related protocol— supported end-to-end by QuesGen as CRO and platform partner.

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Overview

Developed by UCSF-trained neurologist Dale Bredesen, the ReCODE study explored a comprehensive lifestyle-related protocol to reverse neurocognitive decline for patients with Alzheimer’s—considering inflammation, environmental toxins, gut health, and other factors such as diet, exercise, sleep, and stress.

Overarching project goal
Study the reversal of cognitive decline using a protocol designed to address multiple lifestyle-related drivers of Alzheimer’s and cognitive impairment.
Results
The study showed the ReCODE protocol to be effective in reversing neurocognitive decline, with 9 out of 10 participants showing a marked improvement.
At a glance
Client
Four Winds Foundation (via Evanthea, LLC)
Study size
25 participants
Study duration
9 months
Participants
Ages 45–76 with cognitive decline
Relationship
5 years
QuesGen served as the Clinical Research Organization (CRO) and also provided the data management and research platform.

What QuesGen provided

Working closely with the research team, QuesGen delivered a proven data model, development tools, and research processes to support rapid prototyping and piloting—helping the team conduct research more efficiently, with less systematic risk and greater accuracy.

  • Edited the protocol, submitted to the IRB, and worked through identified issues
  • Tracked participants to ensure schedule requirements were met
  • Optimized data curation and analysis using a proven brain health model
  • Enabled continuous improvement of eCRFs, data models, QC, and user experience
Core deliverables
CRO services
IRB + protocol services and study coordination.
Brain health data model
A proven model optimized for brain health research.
eCRF library + custom eCRFs
80+ eCRFs available plus study-specific forms.
Validation + curation
Validate on entry and identify missing or incomplete data.
QuesGen also handled financial aspects of the study, including site and vendor compensation.

Study operations: screening, enrollment, and engagement

QuesGen developed a screening and enrollment process to reduce participant burden and ensure participants meeting requirements were scheduled efficiently. The team also supported participant outreach via a portal with electronic surveys and ePRO/EMA reminders.

Screening + enrollment workflow
Streamlined flow to reduce burden and keep schedules on track.
Participant portal + outreach
Electronic surveys to support ongoing engagement and data capture.
ePRO / EMA reminders
Optional prompts to keep follow-up consistent across the 9-month period.

Why it mattered

ReCODE required coordination, protocol rigor, and data quality controls—without slowing down the team. QuesGen’s combination of CRO services and a proven brain health research platform made it possible to run the study with less friction and more confidence.

Outcome highlights
  • Rapid setup using proven brain health data models and eCRF libraries
  • Validated data capture with centralized curation and QC
  • Participant engagement via portal + electronic surveys and reminders
  • Strong study outcome signal (9/10 showing improvement)
When this approach is a fit

If your study needs both operational rigor (IRB/protocol work, participant tracking, vendor/site coordination) and a flexible platform for validated longitudinal capture, this combination can reduce risk and speed execution.

A single partner across operations + platform
QuesGen supported continuous improvement of encounter processes, user interface, eCRFs, data models, and quality control through the study lifecycle.
Want a well-run study like this? Use the site contact page to book a call.

Turn care plans into measurable outcomes.

Whether you’re running a multi-site study, building a population health program, or enabling person-centered care, QuesGen delivers planning, tracking, and outcomes measurement on one coherent platform.

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